JPH0118916B2 - - Google Patents

Info

Publication number
JPH0118916B2
JPH0118916B2 JP55106775A JP10677580A JPH0118916B2 JP H0118916 B2 JPH0118916 B2 JP H0118916B2 JP 55106775 A JP55106775 A JP 55106775A JP 10677580 A JP10677580 A JP 10677580A JP H0118916 B2 JPH0118916 B2 JP H0118916B2
Authority
JP
Japan
Prior art keywords
group
acid
general formula
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP55106775A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5732289A (en
Inventor
Nobuhiro Ooi
Bunya Aoki
Teizo Shinozaki
Kanji Moro
Toshio Kuroki
Isao Matsunaga
Takao Nofuji
Toshuki Nehashi
Jusuke Harada
Hisao Endo
Takao Kimura
Kana Kojima
Masahiko Matsumoto
Hiroshi Okazaki
Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP10677580A priority Critical patent/JPS5732289A/ja
Priority to AU73549/81A priority patent/AU542522B2/en
Priority to ZA815222A priority patent/ZA815222B/xx
Priority to IL63456A priority patent/IL63456A/xx
Priority to US06/288,402 priority patent/US4355038A/en
Priority to DK343481A priority patent/DK159272C/da
Priority to FI812395A priority patent/FI70220C/fi
Priority to KR1019810002807A priority patent/KR850000049B1/ko
Priority to NO812630A priority patent/NO158300C/no
Priority to CA000383181A priority patent/CA1203530A/en
Priority to DE8181106149T priority patent/DE3167610D1/de
Priority to AT81106149T priority patent/ATE10635T1/de
Priority to MX819591U priority patent/MX6943E/es
Priority to EP81106149A priority patent/EP0045523B1/en
Publication of JPS5732289A publication Critical patent/JPS5732289A/ja
Priority to KR1019840005041A priority patent/KR850000048B1/ko
Publication of JPH0118916B2 publication Critical patent/JPH0118916B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP10677580A 1980-08-05 1980-08-05 Alpha-substituted ureidobenzylpenicillin Granted JPS5732289A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP10677580A JPS5732289A (en) 1980-08-05 1980-08-05 Alpha-substituted ureidobenzylpenicillin
AU73549/81A AU542522B2 (en) 1980-08-05 1981-07-29 Alpha-substituted ureidobenzylpenicillanic acid and process for producing the same
ZA815222A ZA815222B (en) 1980-08-05 1981-07-29 Alpha-substituted ureidobenzylpenicillanic acid and process for the same
IL63456A IL63456A (en) 1980-08-05 1981-07-29 Alpha-((3-(3,4-dihydroxybenzoyl)-3-(substituted(lower alkyl))-1-ureido)-alpha-phenylacetamido)-penicillanic acids,process for producing the same and antibacterial compositions comprising them
US06/288,402 US4355038A (en) 1980-08-05 1981-07-30 α-Substituted ureido-benzylpenicillanic acids
DK343481A DK159272C (da) 1980-08-05 1981-07-31 Analogifremgangsmaade til fremstilling af alfa-substitueret ureidobenzylpenicillansyre
FI812395A FI70220C (fi) 1980-08-05 1981-07-31 Foerfarande foer framstaellning av en ny som antibakteriellt medel anvaendbara alfa-substituerad ureidobensylpenicillansyra
KR1019810002807A KR850000049B1 (ko) 1980-08-05 1981-08-03 α-치환 우레이도 벤질 페니실린 유도체의 제조방법
NO812630A NO158300C (no) 1980-08-05 1981-08-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive alfa-substituerte ureidobenzylpenicillan-syrederivater.
CA000383181A CA1203530A (en) 1980-08-05 1981-08-04 .alpha.-SUBSTITUTED UREIDOBENZYLPENICILLANIC ACID AND PROCESS FOR PRODUCING THE SAME
DE8181106149T DE3167610D1 (en) 1980-08-05 1981-08-05 Alpha-substituted ureidobenzylpenicillanic acid derivatives and process for producing the same
AT81106149T ATE10635T1 (de) 1980-08-05 1981-08-05 Alpha-substituierte ureid obenzylpenizillansaeurederivate und verfahren zu ihrer herstellung.
MX819591U MX6943E (es) 1980-08-05 1981-08-05 Procedimiento para preparar ureidobencilpenicilinas alfa-substituidas
EP81106149A EP0045523B1 (en) 1980-08-05 1981-08-05 Alpha-substituted ureidobenzylpenicillanic acid derivatives and process for producing the same
KR1019840005041A KR850000048B1 (ko) 1980-08-05 1984-08-21 α-치환우레이도 벤질 페니실린 유도체의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10677580A JPS5732289A (en) 1980-08-05 1980-08-05 Alpha-substituted ureidobenzylpenicillin

Publications (2)

Publication Number Publication Date
JPS5732289A JPS5732289A (en) 1982-02-20
JPH0118916B2 true JPH0118916B2 (en]) 1989-04-07

Family

ID=14442271

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10677580A Granted JPS5732289A (en) 1980-08-05 1980-08-05 Alpha-substituted ureidobenzylpenicillin

Country Status (14)

Country Link
US (1) US4355038A (en])
EP (1) EP0045523B1 (en])
JP (1) JPS5732289A (en])
KR (2) KR850000049B1 (en])
AT (1) ATE10635T1 (en])
AU (1) AU542522B2 (en])
CA (1) CA1203530A (en])
DE (1) DE3167610D1 (en])
DK (1) DK159272C (en])
FI (1) FI70220C (en])
IL (1) IL63456A (en])
MX (1) MX6943E (en])
NO (1) NO158300C (en])
ZA (1) ZA815222B (en])

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5810585A (ja) * 1981-07-10 1983-01-21 Chugai Pharmaceut Co Ltd α−置換ウレイドベンジルペニシラン酸
GB2168975A (en) * 1984-12-20 1986-07-02 Procter & Gamble Amides and compositions thereof having anti-inflammatory and analgesic activity
JPH06159622A (ja) * 1992-11-19 1994-06-07 Miura Kenkyusho:Kk 燃焼ガス自己循環式気化燃焼バーナ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32700B1 (en) 1968-02-03 1973-10-31 Beecham Group Ltd Penicillins
GB1250611A (en]) 1968-02-03 1971-10-20
DE1770620A1 (de) 1968-06-12 1971-11-11 Bayer Ag Neue Penicilline
CH562249A5 (en]) 1970-05-25 1975-05-30 Bayer Ag
US3936442A (en) * 1970-05-25 1976-02-03 Bayer Aktiengesellschaft Unreidoacetamido-penicilins
US3978223A (en) * 1970-05-25 1976-08-31 Bayer Aktiengesellschaft Ureidoacetamido-penicillins for treating bacterial infections
US3933795A (en) * 1970-05-25 1976-01-20 Hans-Bodo Konig Ureidoacetamido-penicillins
US3980792A (en) * 1970-05-25 1976-09-14 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
US3939149A (en) * 1970-05-25 1976-02-17 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
US3959258A (en) * 1970-05-25 1976-05-25 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
US4016282A (en) * 1970-05-25 1977-04-05 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
US3974140A (en) * 1970-05-25 1976-08-10 Bayer Aktiengesellschaft Ureidoacetamido-penicillins
GB1433131A (en) 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
DE2258973A1 (de) 1972-12-01 1974-06-06 Bayer Ag Penicilline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1562802A (en) 1976-06-26 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing containing clavulanic acid
JPS5524135A (en) * 1978-08-11 1980-02-21 Chugai Pharmaceut Co Ltd Penicillin derivative and its preparation
JPS54154782A (en) * 1978-05-26 1979-12-06 Chugai Pharmaceut Co Ltd Penicillin derivative and its salt
JPS54163590A (en) * 1978-06-13 1979-12-26 Chugai Pharmaceutical Co Ltd Penicilunic acid derivative and salt thereof
US4229348A (en) * 1978-05-26 1980-10-21 Chugai Seiyaku Kabushiki Kaisha Penicillanic acid derivatives
US4240960A (en) * 1979-03-19 1980-12-23 Bristol-Myers Company Trimethylsilyl substituted penicillins
JPS5583789A (en) 1978-12-18 1980-06-24 Bristol Myers Co Preparation of penicillin

Also Published As

Publication number Publication date
IL63456A0 (en) 1981-10-30
NO158300B (no) 1988-05-09
MX6943E (es) 1986-12-17
DK343481A (da) 1982-02-06
ZA815222B (en) 1982-08-25
EP0045523B1 (en) 1984-12-05
AU7354981A (en) 1982-02-11
AU542522B2 (en) 1985-02-21
KR830006306A (ko) 1983-09-20
EP0045523A1 (en) 1982-02-10
DK159272B (da) 1990-09-24
KR850000048B1 (ko) 1985-02-14
CA1203530A (en) 1986-04-22
FI70220C (fi) 1986-09-15
JPS5732289A (en) 1982-02-20
DE3167610D1 (en) 1985-01-17
NO812630L (no) 1982-02-08
DK159272C (da) 1991-02-18
FI70220B (fi) 1986-02-28
US4355038A (en) 1982-10-19
KR850000049B1 (ko) 1985-02-14
ATE10635T1 (de) 1984-12-15
FI812395L (fi) 1982-02-06
IL63456A (en) 1984-12-31
NO158300C (no) 1988-08-17

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